Transplantation tolerance

Tolerance in Kidney Transplantation

Advances in immunosuppressive treatments led us to better control acute rejection and improve graft survival in organ transplantation. However, immunosuppressive drugs, due to their toxicity, are also responsible for many side effects as opportunistic infections, renal failure, cardiovascular disease and malignancy (Stegall et al, 1997; Soulillou et al, 2001; Ojo et al, 2003; Fishman et al, 200...

Tregs and transplantation tolerance.

The induction and maintenance of immune tolerance to transplanted tissues constitute an active process involving multiple mechanisms that work cooperatively to prevent graft rejection. These mechanisms are similar to inherent tolerance toward self antigens and have a requirement for active immunoregulation, largely T cell mediated, that promotes specific unresponsiveness to donor alloantigens. ...

Tolerance in Renal Transplantation

Transplantation tolerance; myth or reality?

Implication for health policy/practice/research/medical education: Transplantation is now a well-accepted therapy for end organ failure. However the recipients are required to take life-long immunosuppression to prevent rejection. This leads to immunosuppression associated morbidity in the form of viral/ fungal/ bacterial infections in addition to causing financial burden on the system. Over a ...

Transplantation tolerance: fooling mother nature.

Foreignness is threatening. The immune system, the primary arbiter of self and nonself, will reject an organ transplant unless constrained by life-long administration of multiple immune suppressive drugs. Immunosuppressive therapy, while facilitating graft success, heightens susceptibility to infection and the development of malignancy. The challenge then is to educate the immune system to tole...